COMP Protein (AA 21-757) (His tag)
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- Target See all COMP Proteins
- COMP (Cartilage Oligomeric Matrix Protein (COMP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-757
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This COMP protein is labelled with His tag.
- Sequence
- AA 21-757
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 82 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >88 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product COMP Protein
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Cartilage Oligomeric Matrix Protein (COMP) (C-Term) protein
COMP Origin: Rat Recombinant > 95 % (SDS-PAGE)
Cartilage Oligomeric Matrix Protein (COMP) (AA 21-757) protein (His tag)Crystallography grade COMP Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cartilage Oligomeric Matrix Protein (COMP) (AA 20-755) protein (His tag)Crystallography grade COMP Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Target
- COMP (Cartilage Oligomeric Matrix Protein (COMP))
- Alternative Name
- COMP (COMP Products)
- Synonyms
- COMP Protein, EDM1 Protein, EPD1 Protein, MED Protein, PSACH Protein, THBS5 Protein, TSP5 Protein, cartilage oligomeric matrix protein Protein, COMP Protein, sce3551 Protein, CJA_1292 Protein, Comp Protein
- Background
- Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.
- Molecular Weight
- 81.9 kDa
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