TNFRSF21 Protein (AA 42-350) (Fc Tag)

Catalog No. ABIN2181856

Product Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Protein Type: Recombinant

Protein Characteristics: AA 42-350

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TNFRSF21 protein is labelled with Fc Tag.

Sequence: AA 42-350

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: >90 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Target Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Alternative Name: DR6 (TNFRSF21 Products)

Synonyms: TNFRSF21 Protein, tnfrsf21 Protein, MGC146356 Protein, BM-018 Protein, CD358 Protein, DR6 Protein, AA959878 Protein, R74815 Protein, TR7 Protein, dr6 Protein, im:6795346 Protein, wu:fa55e01 Protein, wu:fb02e11 Protein, wu:fc29a09 Protein, wu:fi27h08 Protein, TNF receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily, member 21 Protein, TNFRSF21 Protein, tnfrsf21 Protein, Tnfrsf21 Protein

Background: Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.

Molecular Weight: 60.2 kDa

Pathways: Regulation of Lipid Metabolism by PPARalpha