Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag)

Details for Product No. ABIN2444126, Supplier: Log in to see
Protein Name
  • FCRN
  • alpha-chain
  • FcRn
  • Fc fragment of IgG receptor and transporter
  • Fc receptor, IgG, alpha chain transporter
  • FCGRT
  • Fcgrt
Protein Characteristics
AA 24-297
6
4
3
3
2
1
1
1
1
1
1
1
Origin
Human
10
6
3
3
2
2
Source
HEK-293 Cells
14
4
2
1
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This FCGRT protein is labelled with Strep Tag,Biotin,His tag.
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Brand MABSol®,UltraLys
Specificity The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
Characteristics The subunit FCGRT carries a polyhistidine tag at the C-terminus. The subunit B2M carries a Strep II tag at the C-terminus. The protein has a calculated MW of 31.2 kDa (FCGRT), 13.1 kDa (B2M) . The protein migrates as 33 kDa (FCGRT), 13 kDa (B2M) respectively on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Grade Ultra Sensitive
Background FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecular Weight 31.2 kDa (FCGRT), 13.1 kDa (B2M)
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Comment

A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Supplier Images
SDS-PAGE (SDS) image for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag) (ABIN2444126) Biotinylated Human FcRn / FCGRT & B2M on SDS-PAGE under reducing (R) condition. The g...
Binding Studies (Bind) image for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) (Active) protein (Strep Tag,Biotin,His tag) (ABIN2444126) Immobilized Yervoy Ipilimumab (Human IgG1) at 10 μg/mL (100 μL/well) can bind Biotiny...
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