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RAD51 Protein

RAD51 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as judged from SDS-PAGE analysis Func Active
Catalog No. ABIN2452204
  • Target See all RAD51 Proteins
    RAD51 (DNA Repair Protein Homolog 1 (RAD51))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 7
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Functional Studies (Func)
    Characteristics
    This product was confirmed to possess single strand DNA stimulated ATPase activity.
    Purity
    > 95 % as judged from SDS-PAGE analysis
    Top Product
    Discover our top product RAD51 Protein
  • Application Notes
    1) Studies on homologous recombination in mammals including human
    2) Studies on the interaction of Rad51 protein with various proteins
    3) To be used as a standard for Western blotting
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    20 mM Tris-HCl pH 8.0, 100 mM KCl, 1 mM DTT, 0.5 mM EDTA, 10 % glycerol
    Preservative
    Dithiothreitol (DTT)
    Precaution of Use
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -80 C for long period.
  • Murayama, Kurokawa, Mayanagi, Iwasaki: "Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases." in: Nature, Vol. 451, Issue 7181, pp. 1018-21, (2008) (PubMed).

    Kurumizaka, Aihara, Kagawa, Shibata, Yokoyama: "Human Rad51 amino acid residues required for Rad52 binding." in: Journal of molecular biology, Vol. 291, Issue 3, pp. 537-48, (1999) (PubMed).

  • Target
    RAD51 (DNA Repair Protein Homolog 1 (RAD51))
    Alternative Name
    Rad51 (RAD51 Products)
    Synonyms
    BRCC5 Protein, HRAD51 Protein, HsRad51 Protein, HsT16930 Protein, MRMV2 Protein, RAD51A Protein, RECA Protein, CRAD51 Protein, wu:fb38e12 Protein, zgc:77754 Protein, RGD1563603 Protein, ATRAD51 Protein, F22D1.20 Protein, F22D1_20 Protein, RAS associated with diabetes protein 51 Protein, AV304093 Protein, Rad51a Protein, Reca Protein, brcc5 Protein, rad51 Protein, rad51a Protein, reca Protein, xrad51 Protein, RAD51 recombinase Protein, RAS associated with diabetes protein 51 Protein, RAD51 recombinase L homeolog Protein, RAD51 Protein, rad51 Protein, Rad51 Protein, rad51.L Protein
    Background
    Human Rad51 protein is a functional and structural homolog of E. coli RecA protein, which plays a major role in genetic recombination and recombination repair by mediating strand exchange reaction between homologous DNA strands. Rad51 functionally and physically interacts with its paralogs Dmc1, Rad51B, Rad51C, Rad51D, Xrcc2 and Xrcc3, and also with Rad52 in recombination processes. It also interacts with oncogene proteins and tumor suppressors such as BRCA1, BRCA2, and P53 for the maintenance of genome stability. Rad51 protein was highly purified from E. coli over-expressing human Rad51 protein as a recombinant protein. Since the tag was removed from the recombinant protein (it still contains Gly-Ser-His at the N-terminal), it has been shown to retain nuclear filament forming and strand-exchange activity as well as interaction with Rad52.
    UniProt
    Q06609
    Pathways
    DNA Damage Repair
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