Calreticulin Protein (CALR) (AA 18-417)

Catalog No. ABIN2468306

Product Details

Target: Calreticulin (CALR)

Protein Type: Recombinant

Protein Characteristics: AA 18-417

Origin: Human

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS)

Purity: ~90 %

Application Details

Application Notes: This recombinant protein can be used for WB, ELISA, MS.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM Tris, pH 8.0, 0.002 % NaN, 3 mM NaCl, 2.5 mM

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Storage: -80 °C

Storage Comment: Store in working aliquots at -70 °C.

Target Details

Target: Calreticulin (CALR)

Alternative Name: CALR (CALR Products)

Synonyms: CRT Protein, RO Protein, SSA Protein, cC1qR Protein, crc Protein, crt Protein, Calregulin Protein, CG9429 Protein, Clr Protein, Dmel\\CG9429 Protein, anon-EST:Liang-2.11 Protein, anon-EST:Liang-2.17 Protein, anon-EST:fe3D7 Protein, clone 2.11 Protein, clone 2.17 Protein, eth Protein, potp Protein, cc1qr Protein, ssa Protein, NV19007 Protein, CRP55 Protein, ERp60 Protein, HACBP Protein, CHOT1 Protein, CHT1 Protein, CT1 Protein, AA589632 Protein, CRTR Protein, Creat Protein, CCDS1 Protein, calrl2 Protein, fc66d10 Protein, wu:fc66d10 Protein, wu:fj50c03 Protein, zgc:66153 Protein, calreticulin Protein, calreticulin L homeolog Protein, Calreticulin Protein, putative calreticulin Protein, solute carrier family 6 member 8 Protein, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Protein, CALR Protein, calr.L Protein, Crt Protein, crt Protein, CRT Protein, Calr Protein, calr Protein, LMJF_31_2600 Protein, Crc Protein, Slc6a8 Protein, SLC6A8 Protein, LOC8269812 Protein

Background: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

Molecular Weight: 46 kDa (Calculated)

Gene ID: 811

NCBI Accession: NP_004334

OMIM: 4757900

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response