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Hemagglutinin Protein (HA) (AA 17-338) (His tag,Strep II tag)

HA Origin: Influenza A Virus H5N1 Host: Escherichia coli (E. coli) Recombinant ~95 % ELISA, WB, MS
Catalog No. ABIN2468516
  • Target See all Hemagglutinin (HA) Proteins
    Hemagglutinin (HA)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 17-338
    Origin
    • 16
    • 12
    • 10
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Influenza A Virus H5N1
    Source
    • 62
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This Hemagglutinin protein is labelled with His tag,Strep II tag.
    Application
    ELISA, Western Blotting (WB), Mass Spectrometry (MS)
    Purity
    ~95 %
    Top Product
    Discover our top product HA Protein
  • Application Notes
    This recombinant protein can be used for WB, ELISA, MS.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    1X PBS containing 0.1 % SDS and 0.02 % NaN
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    Storage
    -80 °C
    Storage Comment
    Store in working aliquots at -70 °C.
  • Target
    Hemagglutinin (HA)
    Alternative Name
    Hemagglutinin (HA Products)
    Synonyms
    hemagglutinin Protein, Hemagglutinin Protein, HA Protein, HA Protein, ha Protein
    Target Type
    Influenza Protein
    Background
    Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, but it is in birds that all subtypes can be found (2). These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with host cell surface proteins containing oligosaccharides with terminal sialyl residues. Its extracellular region has two domains (HA1 and HA2) , HA1 is cleaved from the main hemagglutinin protein by the host immune system. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong (3). This more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the efficiency of this type of transmission is low (4). Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability (5). This HA1 recombinant protein is recognized by several ProSci hemagglutinin antibodies.
    Molecular Weight
    39 kDa (Calculated)
    Gene ID
    3654620
    OMIM
    50365729
    UniProt
    Q692M2
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