ITGA4 Protein (AA 131-275) (His tag)
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- Target See all ITGA4 Proteins
- ITGA4 (Integrin alpha 4 (ITGA4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 131-275
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ITGA4 protein is labelled with His tag.
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
- Purity
- ~95 %
- Top Product
- Discover our top product ITGA4 Protein
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Integrin alpha 4 (ITGA4) (AA 790-1032) protein (His-IF2DI Tag)
ITGA4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Integrin alpha 4 (ITGA4) (AA 98-207) protein (GST tag)ITGA4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Integrin alpha 4 (ITGA4) (AA 35-977) protein (His tag)Crystallography grade ITGA4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Integrin alpha 4 (ITGA4) (AA 41-983) protein (His tag)Crystallography grade ITGA4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Integrin alpha 4 (ITGA4) (AA 34-1032) protein (rho-1D4 tag)Crystallography grade ITGA4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Integrin alpha 4 (ITGA4) (AA 41-1039) protein (rho-1D4 tag)Crystallography grade ITGA4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Integrin alpha 4 (ITGA4) protein (Myc-DYKDDDDK Tag)ITGA4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 50 mM Tris pH 7.5, 150 mM NaCl, 5 mM MgCl2
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- ITGA4 (Integrin alpha 4 (ITGA4))
- Alternative Name
- Integrin alpha 4 (ITGA4 Products)
- Synonyms
- CD49D Protein, IA4 Protein, LOC100219853 Protein, integrin subunit alpha 4 Protein, integrin alpha 4 Protein, integrin subunit alpha 4 S homeolog Protein, ITGA4 Protein, Itga4 Protein, itga4.S Protein
- Background
- The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (?4) chain associates with either beta 1 (?1) or beta 7???7) chain. It has been demonstrated that the putative ligand-binding sites of both integrin ?4?1 and ?4?7 is located on the ?4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin ?4?7, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains , this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4? (IN1) (PSI 4827) and Integrin 4? (IN2) (PSI 4837), but not Integrin 4? (CT) (PSI 4783).
- Molecular Weight
- 17 kDa (Calculated)
- Gene ID
- 3676
- NCBI Accession
- NP_000876
- OMIM
- 67191027
- UniProt
- P13612
- Pathways
- Integrin Complex
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