NELL2 Protein (AA 22-238) (His tag)

Catalog No. ABIN2468886

This Recombinant NELL2 protein is expressed in Escherichia coli (E. coli).

Quick Overview for NELL2 Protein (AA 22-238) (His tag) (ABIN2468886)

Target: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Purity: ~95 %

Product Details

Protein Characteristics: AA 22-238

Purification tag / Conjugate: This NELL2 protein is labelled with His tag.

Application Details

Application Notes: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 mM sodium phosphate, 10 mM Tris, 500 mM NaCl, 25 mM imidazole, 2 mM MgCl2, 10 % gycerol

Handling Advice: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Storage: -80 °C

Storage Comment: Store in working aliquots at -70 °C.

Target Details

Target: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Alternative Name: NELL2

Background: NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains (1). It is highly expressed in the hippocampus in vivo (2) and promotes survival of rat primary cultured neurons through activation of JNK and suppression of ERK (3). As ERK is required for the induction of hippocampal long term potentiation (LTP) and JNK appears to be inhibitory on LTP (4,5), it had been suggested that NELL2 may play a role in synaptic plasticity. More recently, NELL2 has been shown to promote differentiation of motor and sensory neurons and stimulates mitogenesis of dorsal root ganglia in chickens (6).

Molecular Weight: 28 kDa (Calculated)

Gene ID: 54003

OMIM: 2494290

UniProt: Q61220