Neurturin (NRTN) (Active) Protein

Details for Product No. ABIN2468895
Protein Name
Origin
Human
9
1
Source
Escherichia coli (E. coli)
8
2
Protein Type
Recombinant
Biological Activity
Active
Options
Sequence MARLGARPCG LRELEVRVSE LGLGYASDET VLFRYCAGAC EAAARVYDLG LRRLRQRRRL RRERVRAQPC CRPTAYEDEV SFLDAHSRYH TVHELSAREC ACV
Characteristics Human Neurturin at a concentration of 100 ng/mL will support the survival of 65 % of newborn rat sympathetic neurons.
Purity < 98 % by SDS-PAGE gel and HPLC analyses.
Endotoxin Level Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
Protein Name
Background Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRalpha2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Gene ID 4902
NCBI Accession NP_004549
OMIM 4758826
UniProt Q99748
Restrictions For Research Use only
Format Lyophilized
Handling Advice As with any protein, exposing Neurturin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Storage -20 °C
Storage Comment The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Neurturin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
Expiry Date 24 months