RCAN2 Protein (AA 2-197, Isoform 2) (His tag)
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- Target See all RCAN2 Proteins
- RCAN2 (Regulator of Calcineurin 2 (RCAN2))
- Protein Type
- Recombinant
- Protein Characteristics
- Isoform 2, AA 2-197
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RCAN2 protein is labelled with His tag.
- Application
- ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)
- Purity
- ~95 %
- Top Product
- Discover our top product RCAN2 Protein
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Regulator of Calcineurin 2 (RCAN2) (AA 1-197) protein (His tag)
RCAN2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Regulator of Calcineurin 2 (RCAN2) (AA 1-225) protein (GST tag)RCAN2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Regulator of Calcineurin 2 (RCAN2) (AA 1-197) protein (Strep Tag)Crystallography grade RCAN2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Regulator of Calcineurin 2 (RCAN2) (AA 1-197) protein (Strep Tag)Crystallography grade RCAN2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 100 mM sodium phosphate, 10 mM Tris, 500 mM NaCl, 25 mM imidazole, 2 mM MgCl2, 10 % gycerol
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- RCAN2 (Regulator of Calcineurin 2 (RCAN2))
- Alternative Name
- RCAN2 (RCAN2 Products)
- Synonyms
- DSCR1L1 Protein, si:ch211-124g24.1 Protein, zgc:85746 Protein, RCAN2 Protein, DKFZp459H071 Protein, rcan2 Protein, CSP2 Protein, MCIP2 Protein, RCN2 Protein, ZAKI-4 Protein, ZAKI4 Protein, Csp2 Protein, Dscr1l1 Protein, Dcip2 Protein, Zaki-4 Protein, regulator of calcineurin 2 Protein, rcan2 Protein, RCAN2 Protein, Rcan2 Protein
- Background
- Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).
- Molecular Weight
- 26 kDa (Calculated)
- Gene ID
- 53901
- OMIM
- 38328420
- UniProt
- Q9JHG2
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