IL1R2 Protein (His tag)

Catalog No. ABIN2566681

Product Details

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL1R2 protein is labelled with His tag.

Application: Western Blotting (WB)

Characteristics:

Measured by its ability to inhibit IL-1 beta dependent proliferation in D10. G4. 1 mouse helper T cells. Approximately 0. 5-3 μg/mL of IL1R2 will inhibit 50 % of the biological response due to 50 pg/mL of recombinant human IL-1 beta.

Purity: >98 % as determined by SDS-PAGE.

Application Details

Application Notes: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -80 °C,-20 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Target Details

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Alternative Name: IL 1 R2 (IL1R2 Products)

Synonyms: CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein

Background: Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Molecular Weight: 38.6 kDa

Gene ID: 7850

NCBI Accession: NP_004624

UniProt: P27930

Pathways: NF-kappaB Signaling