DYNLL1 Protein (Transcript Variant 1) (His tag)

Catalog No. ABIN2712279

Product Details

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This DYNLL1 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human DYNLL1 (transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin Level: < 0.1 EU per μg protein as determined by LAL test

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1 mM DTT, pH 8.0. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Alternative Name: Dynll1 (DYNLL1 Products)

Synonyms: DLC1 Protein, DLC8 Protein, DNCL1 Protein, DNCLC1 Protein, LC8 Protein, LC8a Protein, PIN Protein, hdlc1 Protein, dynll2 Protein, wu:fd56c09 Protein, zgc:73406 Protein, Dlc8 Protein, Dnclc1 Protein, Pin Protein, 8kDLC Protein, lc8 Protein, dlc1 Protein, dlc8 Protein, lc8a Protein, dncl1 Protein, dnclc1 Protein, dynll1a Protein, MGC68763 Protein, CDLC2 Protein, dynll1 Protein, dynll1b Protein, pin Protein, MGC89636 Protein, dynein light chain LC8-type 1 Protein, dynein, light chain, LC8-type 1 Protein, dynein light chain LC8-type 1 S homeolog Protein, dynein light chain LC8-type 1 L homeolog Protein, Dynein light chain 1, cytoplasmic Protein, DYNLL1 Protein, dynll1 Protein, Dynll1 Protein, dynll1.S Protein, dynll1.L Protein, dlc-1 Protein

Background: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Molecular Weight: 12.5 kDa

NCBI Accession: NP_001032583

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity