CRH Protein (His tag)
CRH
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
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- Target See all CRH Proteins
- CRH (Corticotropin Releasing Hormone (CRH))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CRH protein is labelled with His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Corticoliberin (full length, N-term HIS tag) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CRH Protein
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Corticotropin Releasing Hormone (CRH) (AA 154-196) protein (GST tag)
CRH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Corticotropin Releasing Hormone (CRH) (AA 1-196) protein (GST tag)CRH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the N-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- CRH (Corticotropin Releasing Hormone (CRH))
- Alternative Name
- Corticoliberin (CRH Products)
- Synonyms
- CRF Protein, Gm1347 Protein, crf Protein, crh Protein, zgc:101864 Protein, CRH Protein, corticoliberin Protein, crhb Protein, crh.1-a Protein, crha Protein, corticotropin releasing hormone Protein, corticotropin releasing hormone b Protein, corticotropin releasing hormone S homeolog Protein, corticotropin releasing hormone L homeolog Protein, Crh Protein, CRH Protein, crhb Protein, crh Protein, crh.S Protein, crh.L Protein
- Background
- This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer&aposs disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
- Molecular Weight
- 18.9 kDa
- NCBI Accession
- NP_000747
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour
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