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Crk Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

CRK Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2712561
  • Target See all Crk (CRK) Proteins
    Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 1
    Origin
    • 6
    • 1
    • 1
    Human
    Source
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Crk protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human CRK (transcript variant I) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product CRK Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
    Alternative Name
    Crk (CRK Products)
    Synonyms
    CG1587 Protein, CRK Protein, D-CRK Protein, D-Crk Protein, DCrk Protein, Dcrk Protein, Dmel\\CG1587 Protein, crk Protein, dCRK Protein, dCrk Protein, fb34h10 Protein, fc05a01 Protein, fi19g05 Protein, wu:fb34h10 Protein, wu:fc05a01 Protein, wu:fc54a04 Protein, wu:fi19g05 Protein, zgc:100936 Protein, CRKII Protein, p38 Protein, Crko Protein, crk2 Protein, crkII Protein, v-crk Protein, P38C-CRK Protein, Crk-I Protein, Crk-II Protein, Crk-III Protein, Crk3 Protein, CrkIII Protein, c-Crk Protein, Crk oncogene Protein, v-crk avian sarcoma virus CT10 oncogene homolog Protein, CRK proto-oncogene, adaptor protein Protein, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog Protein, v-crk sarcoma virus CT10 oncogene homolog Protein, Crk Protein, crk Protein, CRK Protein, crk.L Protein
    Background
    This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
    Molecular Weight
    22.7 kDa
    NCBI Accession
    NP_005197
    Pathways
    Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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