Calmodulin 1 Protein (Calm1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2713051

Product Details

Target: Calmodulin 1 (Calm1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Calmodulin 1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Calmodulin protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Calmodulin 1 (Calm1)

Alternative Name: Calmodulin (Calm1 Products)

Synonyms: AI256814 Protein, AI327027 Protein, AI461935 Protein, AL024000 Protein, CaM Protein, Calm Protein, CaMI Protein, CALML2 Protein, CAMI Protein, CPVT4 Protein, DD132 Protein, LQT14 Protein, PHKD Protein, caM Protein, calm1 Protein, calm2-a Protein, calm2-b Protein, calm2a Protein, calml2 Protein, cami Protein, dd132 Protein, 3909 Protein, CAM Protein, CG8472 Protein, Cal Protein, Cal49A Protein, CalA Protein, Cam1 Protein, D-CaM Protein, DmCaM Protein, DmCalm Protein, Dmel\CG8472 Protein, anon-EST:Posey59 Protein, cam Protein, dCaM Protein, l(2)03909 Protein, l(2)3909 Protein, lincRNA.S2634 Protein, calmodulin 1 Protein, calmodulin 2 Protein, calmodulin 1 (phosphorylase kinase, delta) L homeolog Protein, Calmodulin Protein, Calm1 Protein, Calm2 Protein, CALM1 Protein, calm1.L Protein, Cam Protein

Background: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 16.7 kDa

NCBI Accession: NP_001734

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Phototransduction, BCR Signaling