Ataxin 1 Protein (ATXN1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all Ataxin 1 (ATXN1) Proteins
- Ataxin 1 (ATXN1)
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Ataxin 1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Ataxin-1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product ATXN1 Protein
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Ataxin 1 (ATXN1) (AA 576-675) protein (GST tag)
ATXN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ataxin 1 (ATXN1) (AA 1-815) protein (Strep Tag)Crystallography grade ATXN1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Ataxin 1 (ATXN1) (AA 1-791) protein (Strep Tag)Crystallography grade ATXN1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Ataxin 1 (ATXN1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)ATXN1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- Ataxin 1 (ATXN1)
- Alternative Name
- Ataxin-1 (ATXN1 Products)
- Synonyms
- ATX1 Protein, D6S504E Protein, SCA1 Protein, ATXN1 Protein, ataxin 1b Protein, atxn1 Protein, 2900016G23Rik Protein, Atx1 Protein, C85907 Protein, ENSMUSG00000074917 Protein, Gm10786 Protein, Sca1 Protein, CG4547 Protein, Dmel\\CG4547 Protein, dAtx-1 Protein, dAtx1 Protein, sca1 Protein, ataxin 1 Protein, ataxin 1b Protein, Ataxin 1 Protein, ATXN1 Protein, atxn1b Protein, Atxn1 Protein, Atx-1 Protein
- Background
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
- Molecular Weight
- 86.7 kDa
- NCBI Accession
- NP_000323
- Pathways
- Synaptic Membrane
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