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Antizyme Inhibitor 1 Protein (AZIN1) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

AZIN1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2715095
  • Target See all Antizyme Inhibitor 1 (AZIN1) Proteins
    Antizyme Inhibitor 1 (AZIN1)
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    • 5
    • 2
    • 1
    • 1
    Human
    Source
    • 2
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Antizyme Inhibitor 1 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human AZIN1 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product AZIN1 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Antizyme Inhibitor 1 (AZIN1)
    Alternative Name
    Azin1 (AZIN1 Products)
    Synonyms
    OAZI Protein, OAZIN Protein, ODC1L Protein, 1700085L02Rik Protein, AI414949 Protein, Oazi Protein, Oazin Protein, AZIN1 Protein, azin1 Protein, oazin Protein, wu:fj32d12 Protein, MGC81852 Protein, wu:fc93f10 Protein, zgc:110131 Protein, antizyme inhibitor 1 Protein, antizyme inhibitor 1b Protein, antizyme inhibitor 1 L homeolog Protein, antizyme inhibitor 1a Protein, AZIN1 Protein, Azin1 Protein, azin1b Protein, azin1.L Protein, azin1 Protein, azin1a Protein
    Background
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.
    Molecular Weight
    49.4 kDa
    NCBI Accession
    NP_680479
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