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DIABLO Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

DIABLO Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2719468
  • Target See all DIABLO Proteins
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 3
    Origin
    • 9
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 9
    • 3
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This DIABLO protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Diablo homolog (Drosophila) (DIABLO), nuclear gene encoding mitochondrial protein, transcript variant 3 (transcript variant 3) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product DIABLO Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Alternative Name
    Diablo Homolog (Drosophila) (Diablo) (DIABLO Products)
    Synonyms
    smac Protein, smac3 Protein, diablo-s Protein, 0610041G12Rik Protein, 1700006L01Rik Protein, AU040403 Protein, Smac Protein, DFNA64 Protein, SMAC Protein, DBO Protein, XSmac Protein, diablo, IAP-binding mitochondrial protein Protein, diablo IAP-binding mitochondrial protein Protein, diablo, IAP-binding mitochondrial protein L homeolog Protein, diablo Protein, Diablo Protein, DIABLO Protein, diablo.L Protein
    Background
    This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Molecular Weight
    15.9 kDa
    NCBI Accession
    NP_620307
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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