ERCC6 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2720440

Product Details

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ERCC6 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human ERCC6 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Alternative Name: Ercc6 (ERCC6 Products)

Synonyms: ARMD5 Protein, CKN2 Protein, COFS Protein, COFS1 Protein, CSB Protein, RAD26 Protein, UVSS1 Protein, 4732403I04 Protein, C130058G22Rik Protein, ercc6 Protein, Ercc6 Protein, ERCC excision repair 6, chromatin remodeling factor Protein, excision repair cross-complementing rodent repair deficiency, complementation group 6 Protein, excision repair cross-complementation group 6 Protein, DNA excision repair protein ERCC-6 Protein, ERCC6 Protein, Ercc6 Protein, ercc6 Protein, LOC100719487 Protein

Background: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3&apos splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.

Molecular Weight: 168.2 kDa

NCBI Accession: NP_000115

Pathways: DNA Damage Repair, Chromatin Binding