Ezrin (EZR) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)

Details for Product No. ABIN2720647
Protein Name
  • CVIL
  • CVL
  • VIL2
  • ezr
  • vil2
  • wu:fc05c03
  • wu:fj31d06
  • cvil
  • cvl
  • Vil2
  • AW146364
  • R75297
  • p81
  • ezr.S
  • ezrin
  • ezrin b
  • ezrin L homeolog
  • EZR
  • ezrb
  • ezr
  • Ezr
  • ezr.L
Protein Characteristics
Transcript Variant 1
4
3
1
1
1
1
Origin
Human
8
1
1
1
Source
HEK-293 Cells
6
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
Myc-DYKDDDDK Tag
Application
Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
Options
Specificity Optimal preservation of protein structure, post-translational modifications and functions.
Characteristics
  • Recombinant human Ezrin (transcript variant 1) protein expressed in HEK293 cells.
  • Produced with end-sequenced ORF clone
Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein Name
Background The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
Molecular Weight 69.2 kDa
NCBI Accession NP_003370
Pathways Maintenance of Protein Location
Application Notes Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays
Comment

The tag is located at the C-terminal.

Restrictions For Research Use only
Concentration > 50 μg/mL
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Storage -80 °C
Storage Comment Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
Supplier Images
Western Blotting (WB) image for Ezrin (EZR) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag) (ABIN2720647) Validation with Western Blot
Product cited in: Sun, Wu, Cai, Wang, Liu, Blot, Shu, Cai: "A prospective study of autoantibodies to Ezrin and pancreatic cancer risk." in: Cancer causes & control : CCC, Vol. 27, Issue 6, pp. 831-5, 2016 (PubMed).

Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: "Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?" in: Human immunology, Vol. 75, Issue 11, pp. 1089-91, 2015 (PubMed).

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