FGD4 Protein (Myc-DYKDDDDK Tag)
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- Target See all FGD4 Proteins
- FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGD4 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human FGD4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product FGD4 Protein
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FYVE, RhoGEF and PH Domain Containing 4 (FGD4) (AA 1-766) protein (Strep Tag)
Crystallography grade FGD4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
FYVE, RhoGEF and PH Domain Containing 4 (FGD4) (AA 1-766) protein (Strep Tag)Crystallography grade FGD4 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))
- Alternative Name
- Fgd4 (FGD4 Products)
- Synonyms
- CMT4H Protein, FRABP Protein, ZFYVE6 Protein, 9030023J02Rik Protein, 9330209B17Rik Protein, Frabp Protein, FYVE, RhoGEF and PH domain containing 4 Protein, FGD4 Protein, Fgd4 Protein
- Background
- This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 86.4 kDa
- NCBI Accession
- NP_640334
- Pathways
- Neurotrophin Signaling Pathway
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