GLN1 Protein (Transcript Variant 1) (His tag)

Catalog No. ABIN2722013

Product Details

Target: GLN1 (Glutamine Synthetase (GLN1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GLN1 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Glutamine synthetase (transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin Level: < 0.1 EU per μg protein as determined by LAL test

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Supplied as a 0.2 μM filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 50 mM Imidazole, pH 8.0

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: GLN1 (Glutamine Synthetase (GLN1))

Alternative Name: Glutamine Synthetase (GLN1 Products)

Synonyms: GLNS Protein, GS Protein, PIG43 Protein, PIG59 Protein, Glns Protein, glutamate-ammonia ligase Protein, glutamate-ammonia ligase (glutamine synthetase) Protein, glutamine synthetase Protein, GLUL Protein, Glul Protein, GLN1 Protein

Background: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.

Molecular Weight: 43.0 kDa

NCBI Accession: NP_002056

Pathways: Positive Regulation of Peptide Hormone Secretion