GRB10 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2722226

Product Details

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 3

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This GRB10 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human GRB10 / GRBIR (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Alternative Name: Grb10,grbir (GRB10 Products)

Synonyms: grb10 Protein, zgc:91987 Protein, GRB10 Protein, grb-10 Protein, grb-ir Protein, irbp Protein, meg1 Protein, rss Protein, LOC100224775 Protein, 5730571D09Rik Protein, AI325020 Protein, Meg1 Protein, mKIAA0207 Protein, RGD1566234 Protein, GRB-IR Protein, Grb-10 Protein, IRBP Protein, MEG1 Protein, RSS Protein, growth factor receptor bound protein 10 Protein, growth factor receptor-bound protein 10a Protein, growth factor receptor bound protein 10 L homeolog Protein, growth factor receptor-bound protein 10 Protein, GRB10 Protein, grb10a Protein, grb10 Protein, grb10.L Protein, LOC100434903 Protein, Grb10 Protein

Background: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 60.7 kDa

NCBI Accession: NP_001001550

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2