KREMEN2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all KREMEN2 Proteins
- KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KREMEN2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Kremen protein 2 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product KREMEN2 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))
- Alternative Name
- Kremen Protein 2 (KREMEN2 Products)
- Synonyms
- krm2 Protein, KREMEN2 Protein, MGC147633 Protein, KRM2 Protein, 2900054E04Rik Protein, Krm2 Protein, kringle containing transmembrane protein 2 S homeolog Protein, kringle containing transmembrane protein 2 Protein, kremen2.S Protein, KREMEN2 Protein, kremen2 Protein, Kremen2 Protein
- Background
- This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
- Molecular Weight
- 42.3 kDa
- NCBI Accession
- NP_078783
- Pathways
- WNT Signaling
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