MAPK14 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2725276

Product Details

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MAPK14 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human MAP kinase p38 alpha / MAPK14 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Alternative Name: Map Kinase p38 Alpha,mapk14 (MAPK14 Products)

Synonyms: CSBP Protein, CSBP1 Protein, CSBP2 Protein, CSPB1 Protein, EXIP Protein, Mxi2 Protein, PRKM14 Protein, PRKM15 Protein, RK Protein, SAPK2A Protein, p38 Protein, p38ALPHA Protein, CRK1 Protein, Csbp1 Protein, Csbp2 Protein, Exip Protein, Hog Protein, Prkm14 Protein, Prkm15 Protein, Sapk2A Protein, p38Hog Protein, p38alpha Protein, p38b Protein, zp38b Protein, MAPK14 Protein, 186F5S Protein, BG:DS00797.3 Protein, CG7393 Protein, D-p38 Protein, D-p38 MAPK Protein, D-p38b Protein, Dm p38b Protein, Dmel\\CG7393 Protein, Dmp38b Protein, Dp38 Protein, Dp38b Protein, ESTS:186F5S Protein, Mpk34C Protein, anon-sts23 Protein, dp38b Protein, p38 MAPK Protein, p38 beta Protein, p38B Protein, p38Kb Protein, p38beta Protein, Crk1 Protein, p38-alpha Protein, p38MAPK Protein, p38a Protein, csbp Protein, mapk14a Protein, mxi2 Protein, sapk2 Protein, sapk2a Protein, AP22.98 Protein, AP22_98 Protein, ATMPK14 Protein, mitogen-activated protein kinase 14 Protein, SAPK2a Protein, MAP kinase 14A Protein, MAP kinase p38a Protein, MAPK 14A Protein, fk28c03 Protein, hm:zeh1243 Protein, wu:fk28c03 Protein, zp38a Protein, P38C-CRK Protein, mitogen-activated protein kinase 14 Protein, mitogen activated protein kinase 14 Protein, mitogen-activated protein kinase 14b Protein, p38b MAP kinase Protein, mitogen-activated protein kinase 14 S homeolog Protein, mitogen-activated protein kinase 14a Protein, CRK proto-oncogene, adaptor protein Protein, MAPK14 Protein, Mapk14 Protein, mapk14b Protein, p38b Protein, mapk14.S Protein, MPK14 Protein, mapk14a Protein, CRK Protein

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 41.3 kDa

NCBI Accession: NP_001306

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins