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MCM4 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

MCM4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2725632
  • Target See all MCM4 Proteins
    MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This MCM4 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human MCM4 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product MCM4 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
    Alternative Name
    Mcm4 (MCM4 Products)
    Synonyms
    cdc21 Protein, CDC21 Protein, CDC54 Protein, NKCD Protein, NKGCD Protein, P1-CDC21 Protein, hCdc21 Protein, 19G Protein, AI325074 Protein, AU045576 Protein, Cdc21 Protein, Mcmd4 Protein, mKIAA4003 Protein, mcdc21 Protein, cb1025 Protein, fc12c09 Protein, fj85g09 Protein, hm:zeh1616 Protein, wu:fc12c09 Protein, wu:fj85g09 Protein, zeh1616 Protein, minichromosome maintenance complex component 4 L homeolog Protein, minichromosome maintenance complex component 4 S homeolog Protein, minichromosome maintenance complex component 4 Protein, mcm4.L Protein, mcm4.S Protein, MCM4 Protein, mcm4 Protein, Mcm4 Protein
    Background
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
    Molecular Weight
    96.4 kDa
    NCBI Accession
    NP_877423
    Pathways
    DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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