NACA Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2726773

Product Details

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 4

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NACA protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human NACA (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Alternative Name: Naca (NACa1 Products)

Synonyms: AL022831 Protein, AL024382 Protein, Gm1878 Protein, mKIAA0363 Protein, skNAC Protein, ik:tdsubc_2b5 Protein, nkn Protein, tdsubc_2b5 Protein, xx:tdsubc_2b5 Protein, NACA1 Protein, nascent polypeptide-associated complex alpha polypeptide Protein, nascent polypeptide-associated complex alpha subunit Protein, Naca Protein, naca Protein, NACA Protein

Background: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.

Molecular Weight: 23.2 kDa

NCBI Accession: NP_001106673

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development