PCSK2 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2727048

Product Details

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PCSK2 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human NEC2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Alternative Name: Nec2 (PCSK2 Products)

Synonyms: NEC 2 Protein, NEC-2 Protein, NEC2 Protein, PC2 Protein, SPC2 Protein, PCSK2 Protein, 6330411F23Rik Protein, AI839700 Protein, Nec-2 Protein, Nec2 Protein, Phpp-2 Protein, pc2 Protein, nec2 Protein, spc2 Protein, pcsk2 Protein, pcsk2-A Protein, proprotein convertase subtilisin/kexin type 2 Protein, proprotein convertase subtilisin/kexin type 2 L homeolog Protein, PCSK2 Protein, pcsk2 Protein, Pcsk2 Protein, pcsk2.L Protein

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 67.9 kDa

NCBI Accession: NP_002585

Pathways: Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity