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WHSC2 Protein (Myc-DYKDDDDK Tag)

WHSC2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2727089
  • Target See all WHSC2 Proteins
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Protein Type
    Recombinant
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This WHSC2 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human NELF-A protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product WHSC2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Alternative Name
    Nelf-A (WHSC2 Products)
    Synonyms
    BcDNA:SD07139 Protein, CG5874 Protein, Dmel\\CG5874 Protein, NELF Protein, NELF-A Protein, Whsc2 Protein, fi75f03 Protein, whsc2 Protein, wu:fi75f03 Protein, MGC85474 Protein, WHSC2 Protein, nelfa Protein, nelf-a Protein, p/okcl.15 Protein, Whsc2h Protein, Negative elongation factor A Protein, negative elongation factor complex member A Protein, negative elongation factor complex member A L homeolog Protein, negative elongation factor complex member A, Whsc2 Protein, Nelf-A Protein, Nelfa Protein, nelfa Protein, nelfa.L Protein, NELFA Protein
    Background
    This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
    Molecular Weight
    57.1 kDa
    NCBI Accession
    NP_005654
    Pathways
    Chromatin Binding
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