NLRP10 Protein (Myc-DYKDDDDK Tag)
(1 reference)-
- Target See all NLRP10 Proteins
- NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NLRP10 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human NLRP10 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NLRP10 Protein
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NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 1-655) protein (His tag)
Crystallography grade NLRP10 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 1-673) protein (His tag)Crystallography grade NLRP10 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 205-15, (2014) (PubMed).
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: "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 205-15, (2014) (PubMed).
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- Target
- NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))
- Alternative Name
- Nlrp10 (NLRP10 Products)
- Synonyms
- CLR11.1 Protein, NALP10 Protein, NOD8 Protein, PAN5 Protein, PYNOD Protein, 6430548I20Rik Protein, Nalp10 Protein, Napl10 Protein, Pynod Protein, NLR family pyrin domain containing 10 Protein, NLR family, pyrin domain containing 10 Protein, NLRP10 Protein, Nlrp10 Protein
- Background
- Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
- Molecular Weight
- 74.9 kDa
- NCBI Accession
- NP_789791
- Pathways
- Inflammasome
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