PDP Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2728599

Product Details

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 4

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PDP protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human PDP1 (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: Pdp1 (PDP Products)

Synonyms: 153332_at Protein, CG12151 Protein, Dmel\\CG12151 Protein, PDP Protein, pdp Protein, PDH Protein, PDPC Protein, PPM2C Protein, Gm1024 Protein, Ppm2c Protein, im:7157162 Protein, zgc:174908 Protein, pdp1 Protein, ppm2c Protein, Pyruvate dehydrogenase phosphatase Protein, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial Protein, pyruvate dehyrogenase phosphatase catalytic subunit 1 Protein, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog Protein, Pdp Protein, LOC413080 Protein, PDP1 Protein, Pdp1 Protein, pdp1 Protein, pdp1.L Protein

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].

Molecular Weight: 60.9 kDa

NCBI Accession: NP_001155253