PEN2 Protein (Myc-DYKDDDDK Tag)
-
- Target See all PEN2 (PSENEN) Proteins
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PEN2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human PEN2 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PSENEN Protein
-
Presenilin Enhancer 2 Homolog (PSENEN) (AA 1-101) protein (GST tag)
PSENEN Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Presenilin Enhancer 2 Homolog (PSENEN) (AA 1-101) protein (rho-1D4 tag)Crystallography grade PSENEN Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Presenilin Enhancer 2 Homolog (PSENEN) (AA 1-101) protein (rho-1D4 tag)Crystallography grade PSENEN Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
- Alternative Name
- Pen2 (PSENEN Products)
- Background
- Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer&aposs disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
- Molecular Weight
- 11.8 kDa
- NCBI Accession
- NP_758844
- Pathways
- Notch Signaling, Neurotrophin Signaling Pathway
-
