FXYD1 Protein (Transcript Variant A) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2728859

Product Details

Target: FXYD1 (FXYD Domain Containing Ion Transport Regulator 1 (FXYD1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant A

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FXYD1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Phospholemman (transcript variant a) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: FXYD1 (FXYD Domain Containing Ion Transport Regulator 1 (FXYD1))

Alternative Name: Phospholemman (FXYD1 Products)

Synonyms: PLM Protein, 0610012C17Rik Protein, 1110006M24Rik Protein, Plm Protein, Pml Protein, FXYD domain containing ion transport regulator 1 Protein, FXYD domain-containing ion transport regulator 1 Protein, FXYD1 Protein, Fxyd1 Protein

Background: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

Molecular Weight: 8.3 kDa

NCBI Accession: NP_005022