PSTPIP1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2730031

Product Details

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PSTPIP1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human PSTPIP1 / CD2BP1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Alternative Name: Pstpip1,cd2bp1 (PSTPIP1 Products)

Synonyms: cd2bp1 Protein, cd2bp1l Protein, cd2bp1s Protein, h-pip Protein, papas Protein, pstpip Protein, PSTPIP1 Protein, CD2BP1 Protein, CD2BP1L Protein, CD2BP1S Protein, H-PIP Protein, PAPAS Protein, PSTPIP Protein, def-2 Protein, proline-serine-threonine phosphatase interacting protein 1 Protein, proline-serine-threonine phosphatase interacting protein 1 S homeolog Protein, proline-serine-threonine phosphatase-interacting protein 1 Protein, PSTPIP1 Protein, pstpip1.S Protein, pstpip1 Protein, Pstpip1 Protein

Background: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Molecular Weight: 47.4 kDa

NCBI Accession: NP_003969