RAB7A Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2730367

Product Details

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This RAB7A protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human RAB7A / RAB7 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: "Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7." in: Molecular cancer research : MCR, Vol. 10, Issue 6, pp. 713-26, (2012) (PubMed).

Target Details

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Alternative Name: Rab7a,rab7 (RAB7A Products)

Synonyms: RAB5 Protein, PRO2706 Protein, RAB7 Protein, Rab7 Protein, rab7 Protein, pro2706 Protein, RAB7A Protein, LOC100231734 Protein, ARABIDOPSIS RAB GTPASE HOMOLOG G2 Protein, ATRAB7A Protein, ATRABG2 Protein, F7D8.20 Protein, F7D8_20 Protein, RAB GTPase homolog 7A Protein, DDBDRAFT_0190210 Protein, DDBDRAFT_0191507 Protein, DDB_0190210 Protein, DDB_0191507 Protein, Rab7a Protein, rab-7 Protein, zgc:64058 Protein, RAB5A, member RAS oncogene family Protein, RAB7A, member RAS oncogene family Protein, RAB7A, member RAS oncogene family L homeolog Protein, rab7A protein Protein, RAB GTPase homolog 7A Protein, Rab GTPase Protein, ras-related protein rab-7a Protein, RAB7, member RAS oncogene family Protein, RAB5A Protein, RAB7A Protein, Rab7a Protein, rab7a.L Protein, rab7a Protein, rab7A Protein, Rab7 Protein, rab7 Protein

Background: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

Molecular Weight: 23.3 kDa

NCBI Accession: NP_004628

Pathways: EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome