Quick Overview for p130 Protein (Myc-DYKDDDDK Tag) (ABIN2730602)
Target
See all p130 (RBL2) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This p130 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human RBL2 / p130 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Retinoblastoma-Like 2 (p130) (RBL2) (AA 1-1135) protein (His tag)
custom-made RBL2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Retinoblastoma-Like 2 (p130) (RBL2) (AA 1-1139) protein (His tag)custom-made RBL2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
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Alternative Name
- Rbl2,p130
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Background
- Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. [UniProtKB/Swiss-Prot Function]
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Molecular Weight
- 128.2 kDa
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NCBI Accession
- NP_005602
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Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
Target
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