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p130 Protein (Myc-DYKDDDDK Tag)

RBL2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2730602
  • Target See all p130 (RBL2) Proteins
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    Protein Type
    Recombinant
    Origin
    • 2
    • 1
    Human
    Source
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This p130 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human RBL2 / p130 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product RBL2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    Alternative Name
    Rbl2,p130 (RBL2 Products)
    Synonyms
    RBL2 Protein, RBR2 Protein, RRB2a Protein, PRB2 Protein, RBR-2 Protein, Rb2 Protein, p130 Protein, P130 Protein, retinoblastoma-like 2 (p130) Protein, RB transcriptional corepressor like 2 Protein, related to retinoblastoma 2 Protein, RBL2 Protein, LOC541652 Protein, Rbl2 Protein
    Background
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. [UniProtKB/Swiss-Prot Function]
    Molecular Weight
    128.2 kDa
    NCBI Accession
    NP_005602
    Pathways
    Cell Division Cycle, Mitotic G1-G1/S Phases
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