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Shugoshin Protein (Myc-DYKDDDDK Tag)

SGOL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2731936
  • Target See all Shugoshin (SGOL1) Proteins
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Protein Type
    Recombinant
    Origin
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Shugoshin protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human SGOL1 / SGO1 (transcript variant B1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product SGOL1 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Alternative Name
    Sgol1,sgo1 (SGOL1 Products)
    Synonyms
    sgo1 Protein, NY-BR-85 Protein, SGO Protein, Sgo1 Protein, 3300001M08Rik Protein, C81037 Protein, shugoshin 1 Protein, shugoshin centromeric cohesion 1 Protein, shugoshin 1 L homeolog Protein, Sgo1 Protein, sgo1 Protein, sgo1.L Protein, SGO1 Protein
    Background
    The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
    Molecular Weight
    31.1 kDa
    NCBI Accession
    NP_001012411
    Pathways
    Maintenance of Protein Location
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