SOCS6 Protein (His tag)

Catalog No. ABIN2732346

Product Details

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SOCS6 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human SOCS6 / CIS4 (full length, N-term HIS tag) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: Socs6,cis4 (SOCS6 Products)

Synonyms: CIS-4 Protein, CIS4 Protein, HSPC060 Protein, SOCS-4 Protein, SOCS-6 Protein, SOCS4 Protein, SSI4 Protein, STAI4 Protein, STATI4 Protein, socs6 Protein, MGC81477 Protein, SOCS6 Protein, 1500012M23Rik Protein, 5830401B18Rik Protein, AI447482 Protein, Cis4 Protein, Cish4 Protein, Socs4 Protein, socs6l Protein, zgc:64107 Protein, wu:fb77f06 Protein, suppressor of cytokine signaling 6 Protein, suppressor of cytokine signaling 6 L homeolog Protein, suppressor of cytokine signaling Protein, suppressor of cytokine signaling 6b Protein, SOCS6 Protein, Socs6 Protein, socs6.L Protein, socs6 Protein, socs6b Protein

Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Molecular Weight: 59.5

NCBI Accession: NP_004223

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis