SPAG6 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2732491

Product Details

Target: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SPAG6 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human SPAG6 / PF16 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Alternative Name: Spag6,pf16 (SPAG6 Products)

Synonyms: Repro-SA-1 Protein, pf16 Protein, PF16 Protein, RGD1310892 Protein, zgc:91805 Protein, SPAG6 Protein, repro-sa-1 Protein, DKFZp459D035 Protein, sperm associated antigen 6 Protein, sperm associated antigen 6-like Protein, sperm associated antigen 6 L homeolog Protein, SPAG6 Protein, Spag6l Protein, Spag6 Protein, spag6 Protein, spag6.L Protein

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 49.5 kDa

NCBI Accession: NP_758442