TAB1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2733155

Product Details

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TAB1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human TAB1 / MAP3K7IP1 (transcript variant alpha) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Alternative Name: Tab1,map3k7ip1 (TAB1 Products)

Synonyms: 3'-Tab1 Protein, MAP3K7IP1 Protein, 2310012M03Rik Protein, Map3k7ip1 Protein, b2b449Clo Protein, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Protein, TGF-beta activated kinase 1/MAP3K7 binding protein 1 Protein, TAB1 Protein, Tab1 Protein

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Molecular Weight: 54.5 kDa

NCBI Accession: NP_006107

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades