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TCF3 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

TCF3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2733358
  • Target See all TCF3 Proteins
    TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    • 4
    • 2
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This TCF3 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human TCF3 / E2A (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product TCF3 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
    Alternative Name
    Tcf3,e2a (TCF3 Products)
    Synonyms
    E2A Protein, E47 Protein, ITF1 Protein, TCF-3 Protein, VDIR Protein, bHLHb21 Protein, tcf3a Protein, zgc:113045 Protein, A1 Protein, AA408400 Protein, ALF2 Protein, AW209082 Protein, E12 Protein, E12/E47 Protein, ME2 Protein, Pan1 Protein, Pan2 Protein, Tcfe2a Protein, bhlhb21 Protein, e2a Protein, itf1 Protein, tcfe2a Protein, vdir Protein, xtcf-3 Protein, xtcf3 Protein, G12 Protein, TCF7L1 Protein, XE3 Protein, transcription factor 3 Protein, transcription factor 3b Protein, transcription factor 3 L homeolog Protein, transcription factor E2a Protein, TCF3 Protein, tcf3b Protein, Tcf3 Protein, tcf3.L Protein, tcfe2a Protein
    Background
    This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(119), with PBX1), childhood leukemia (t(1919), with TFPT) and acute leukemia (t(1219), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
    Molecular Weight
    67.1 kDa
    NCBI Accession
    NP_001129611
    Pathways
    WNT Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response
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