THRB Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all THRB Proteins
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This THRB protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human THRB / ERBA2 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product THRB Protein
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Thyroid Hormone Receptor, beta (THRB) (AA 1-110) protein (GST tag)
THRB Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Thyroid Hormone Receptor, beta (THRB) (AA 1-461) protein (Strep Tag)Crystallography grade THRB Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Thyroid Hormone Receptor, beta (THRB) (AA 1-461) protein (Strep Tag)Crystallography grade THRB Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Alternative Name
- Thrb,erba2 (THRB Products)
- Synonyms
- C-ERBA-2 Protein, C-ERBA-BETA Protein, ERBA2 Protein, GRTH Protein, NR1A2 Protein, PRTH Protein, THR1 Protein, THRB1 Protein, THRB2 Protein, Nr1a2 Protein, T3R[b] Protein, T3Rbeta Protein, Thrb1 Protein, Thrb2 Protein, c-erbAbeta Protein, TR-beta Protein, TR[b]1 Protein, fj24f03 Protein, trb Protein, wu:fj24f03 Protein, CTR BETA 2 Protein, TR-BETA Protein, LOC734147 Protein, thrb Protein, THRB Protein, C-erba-beta Protein, RATT3REC Protein, T3rec Protein, TRbeta Protein, THR Protein, TRbeta1 Protein, thyroid hormone receptor beta Protein, thyroid hormone receptor, beta Protein, thyroid hormone receptor, beta S homeolog Protein, thyroid hormone receptor, beta L homeolog Protein, THRB Protein, Thrb Protein, thrb Protein, thrb.S Protein, thrb.L Protein
- Background
- The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
- Molecular Weight
- 52.6 kDa
- NCBI Accession
- NP_001121648
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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