TRAF2 Protein (Myc-DYKDDDDK Tag)
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- Target See all TRAF2 Proteins
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TRAF2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human TRAF2 / TRAP3 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product TRAF2 Protein
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TNF Receptor-Associated Factor 2 (TRAF2) (AA 306-501) protein (His-IF2DI Tag)
TRAF2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
TNF Receptor-Associated Factor 2 (TRAF2) (AA 1-501) protein (GST tag)TRAF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
TNF Receptor-Associated Factor 2 (TRAF2) (AA 2-501) protein (His tag)Crystallography grade TRAF2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
TNF Receptor-Associated Factor 2 (TRAF2) (AA 2-501) protein (His tag)Crystallography grade TRAF2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
- Alternative Name
- Traf2,trap3 (TRAF2 Products)
- Synonyms
- MGC:45012 Protein, TRAP Protein, TRAP3 Protein, TANK Protein, AI325259 Protein, TNF-receptor-associated factor 2 Protein, conjugal transfer protein TraF Protein, TNF receptor associated factor 2 Protein, TNF receptor-associated factor 2 Protein, Tnf receptor-associated factor 2 Protein, LOC661716 Protein, traF2 Protein, TRAF2 Protein, Traf2 Protein
- Background
- The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
- Molecular Weight
- 55.7 kDa
- NCBI Accession
- NP_066961
- Pathways
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins
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