UGT1A4 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2734991

Product Details

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This UGT1A4 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human UGT1A4 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Alternative Name: Ugt1a4 (UGT1A4 Products)

Synonyms: HUG-BR2 Protein, UDPGT Protein, UDPGT 1-4 Protein, UGT-1D Protein, UGT1-04 Protein, UGT1.4 Protein, UGT1D Protein, UGT1 Protein, UGT1A4 Protein, UDP glucuronosyltransferase family 1 member A4 Protein, UDP-glucuronosyltransferase 1-4 Protein, UGT1A4 Protein, UGT1-4 Protein

Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Molecular Weight: 57 kDa

NCBI Accession: NP_009051

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha