Vitamin D Receptor Protein (VDR) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2735370

Product Details

Target: Vitamin D Receptor (VDR)

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Chemical

Source: HEK-293 Cells

Purification tag / Conjugate: This Vitamin D Receptor protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Vitamin D3 receptor / NR1I1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Vitamin D Receptor (VDR)

Alternative Name: Vitamin d3 Receptor,nr1i1 (VDR Products)

Synonyms: vdrbeta Protein, vdr0 Protein, LOC100136219 Protein, NR1I1-B Protein, gb:dq017633 Protein, vdr-b Protein, Ci-VDR-b Protein, VDR Protein, LOC100221284 Protein, vdr-A Protein, xVDR Protein, Nr1i1 Protein, vdr Protein, NR1I1 Protein, PPP1R163 Protein, vitamin D (1,25- dihydroxyvitamin D3) receptor Protein, vitamin D receptor Protein, vitamin D3 receptor A Protein, vitamin D receptor b Protein, nuclear receptor VDR-b Protein, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog Protein, vitamin D (1,25-dihydroxyvitamin D3) receptor Protein, vitamin D receptor a Protein, vdr Protein, vdr0 Protein, VDR Protein, LOC100136219 Protein, vdrb Protein, vdr-b Protein, vdr.L Protein, Vdr Protein, vdra Protein

Target Type: Chemical

Background: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

Molecular Weight: 48.1 kDa

NCBI Accession: NP_001017535

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway