FZD5 Protein (AA 27-180) (Fc Tag)
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- Target See all FZD5 Proteins
- FZD5 (Frizzled Family Receptor 5 (FZD5))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 27-180
- Origin
- Human, Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FZD5 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human and mouse Wnt3a.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
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Frizzled Family Receptor 5 (FZD5) (AA 27-238) protein (His tag)Crystallography grade FZD5 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
Frizzled Family Receptor 5 (FZD5) (AA 27-238) protein (His tag)Crystallography grade FZD5 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
Frizzled Family Receptor 5 (FZD5) (AA 27-585) protein (rho-1D4 tag)Crystallography grade FZD5 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
Frizzled Family Receptor 5 (FZD5) (AA 27-585) protein (rho-1D4 tag)Crystallography grade FZD5 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
Frizzled Family Receptor 5 (FZD5) (AA 27-167) protein (Fc Tag)FZD5 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Inhibits Wnt3a activation in a stoechiometric manner.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- FZD5 (Frizzled Family Receptor 5 (FZD5))
- Alternative Name
- Frizzled-5 (FZD5 Products)
- Synonyms
- C2orf31 Protein, HFZ5 Protein, 5330434N09Rik Protein, AI427138 Protein, Fz-5 Protein, Fz5 Protein, mFz5 Protein, Xfz5 Protein, frizzled5 Protein, frizzled5a Protein, fz5 Protein, fzd5-A Protein, fz2 Protein, fz8c Protein, fzd8c Protein, zg02 Protein, frizzled class receptor 5 Protein, frizzled class receptor 5 S homeolog Protein, FZD5 Protein, Fzd5 Protein, fzd5.S Protein, fzd5 Protein
- Background
- Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.
- Molecular Weight
- ~50kDa (SDS-PAGE)
- UniProt
- Q13467
- Pathways
- WNT Signaling
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