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Angiopoietin 2 Protein (ANGPT2) (AA 275-496) (His tag)

ANGPT2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
Catalog No. ABIN2870605
  • Target See all Angiopoietin 2 (ANGPT2) Proteins
    Angiopoietin 2 (ANGPT2)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 275-496
    Origin
    • 21
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Source
    • 17
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Angiopoietin 2 protein is labelled with His tag.
    Sequence
    AA 275-496
    Characteristics
    This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >95 % as determined by reduced SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product ANGPT2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    20  mM MOPS, 150  mM NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Kang, Kim, Jeong, Im: "Angiopoietin-2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells." in: Journal of cellular biochemistry, Vol. 118, Issue 9, pp. 2896-2908, (2017) (PubMed).

  • Target
    Angiopoietin 2 (ANGPT2)
    Alternative Name
    Angiopoietin-2 (ANGPT2 Products)
    Synonyms
    AGPT2 Protein, ANG2 Protein, Agpt2 Protein, Ang-2 Protein, Ang2 Protein, ang2 Protein, angpt2 Protein, ANGIOPOIETIN-2 Protein, ANG-2 Protein, ANGPT2 Protein, Angrp Protein, Rnase5b Protein, ANG3 Protein, C11orf2 Protein, C11orf3 Protein, FFR Protein, angiopoietin 2 Protein, angiopoietin 2b Protein, angiogenin, ribonuclease A family, member 2 Protein, VPS51, GARP complex subunit Protein, ANGPT2 Protein, Angpt2 Protein, angpt2b Protein, Ang2 Protein, VPS51 Protein
    Background
    Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.
    Molecular Weight
    26.3 kDa
    Pathways
    RTK Signaling
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