Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CTLA4 Protein (AA 36-162) (His tag)

CTLA4 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Catalog No. ABIN2870729
  • Target See all CTLA4 Proteins
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 36-162
    Origin
    • 42
    • 20
    • 6
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Mouse
    Source
    • 33
    • 19
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CTLA4 protein is labelled with His tag.
    Sequence
    AA 36-162
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CTLA4 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

  • Target
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Alternative Name
    CTLA-4 (CTLA4 Products)
    Synonyms
    CTLA-4 Protein, CTLA4 Protein, CD152 Protein, Cd152 Protein, Ctla-4 Protein, Ly-56 Protein, CD Protein, CELIAC3 Protein, GRD4 Protein, GSE Protein, IDDM12 Protein, sCTLA4 Protein, cytotoxic T-lymphocyte associated protein 4 Protein, cytotoxic T-lymphocyte-associated protein 4 Protein, CTLA4 Protein, Ctla4 Protein
    Background
    CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
    Molecular Weight
    15.9 kDa
    NCBI Accession
    NP_033973
    Pathways
    Cancer Immune Checkpoints
You are here:
Support