Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 4 (DYRK4) (Active) protein (GST tag)

Details for Product No. ABIN2960621, Supplier: Log in to see
Protein Name
  • DYRK4
  • AW049118
  • Dyrk4a
  • Dyrk4b
  • Rad51ap1
  • dual specificity tyrosine phosphorylation regulated kinase 4
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
  • DYRK4
  • dyrk4
  • Dyrk4
Origin
Human
5
1
Source
Baculovirus infected Insect Cells
4
2
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This DYRK4 protein is labelled with GST tag.
Application
Functional Studies (Func), Western Blotting (WB)
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Characteristics Recombinant full-length human DYRK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Name
Background DYRK4 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 plays an important role in cell proliferation, survival, and development (1). Northern blot analysis shows DYRK4 is highly expressed in the testis with a very restricted expression to stage VIII postmeiotic spermatids (2). Analysis of a DYRK4 deficient mouse line showed that DYRK4 is dispensable for male fertility, hence suggesting a functional redundancy of some DYRK isoforms during spermiogenesis. DYRK4 protein contains a DYRK homology box in its N-terminal half, followed by a central kinase domain with a YxY loop.
Synonyms: None
Molecular Weight ~90 kDa
NCBI Accession NM_003845
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Handling Advice For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Storage -80 °C
Storage Comment Store product at -70 °C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
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